Ultra-flexible wireless endovascular stimulator for cortical simulation

Abstract

Objective. Endovascular neural stimulation (ENS) offers a minimally invasive alternative to conventional intra-cranial implants. However, present ENS devices rely on long transvascular leads, which are prone to foreign body responses, breakage, higher impedance, and noisy input. In this study, we aimed to demonstrate the feasibility of fully wireless cortical stimulation using an ultra-flexible, leadless endovascular stimulator that can be delivered with standard neurointerventional techniques. Approach. We designed an ENS implant integrating a miniaturized receiver coil, passive rectification circuitry, and an electrode pair on a flexible substrate that can be rolled into a catheter and sel..